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Article

GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct.

PloS one - 1 Jan 2013

Sasaki Motoko, Matsubara Takashi, Nitta Takeo, Sato Yasunori, Nakanuma Yasuni

Abstract excerpt

Intraductal papillary neoplasms of the bile duct (IPNB) shows favorable prognosis and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Although activating point mutations of GNAS at codon 201 have been detected in approximately two thirds of IPMNs of the pancreas, there have been few studies on GNAS mutations in IPNBs. This study investigates the status of...

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Share to Bile Duct Neoplasms
Share to Bile Ducts, Intrahepatic
Share to Chromogranins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Mucins

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24312577
DOI: 10.1371/journal.pone.0081706
PMCID: PMC3847161

Genes

GNAS
KRAS
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct.PMID 24312577Read ↗

GNAS Is frequently mutated in a specific subgroup of intraductal papillary neoplasms of the bile duct.Semantic proximity Read ↗

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.Semantic proximity Read ↗

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report.Semantic proximity Read ↗

Intraductal Papillary Neoplasm of Bile Duct: Updated Clinicopathological Characteristics and Molecular and Genetic AlterationsSemantic proximity Read ↗

GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.Semantic proximity Read ↗

Intraductal papillary neoplasms of the bile duct consist of two distinct types specifically associated with clinicopathological features and molecular phenotypes.Semantic proximity Read ↗

Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation.Semantic proximity Read ↗

Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts.Semantic proximity Read ↗

GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".Semantic proximity Read ↗

KRAS mutation and immunohistochemical profile in intraductal papillary neoplasm of the intrahepatic bile ducts.Semantic proximity Read ↗

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