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Article

Integrated genomic profiling, therapy response, and survival in adult acute myelogenous leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2015

Parkin Brian, Ouillette Peter, Yildiz Mehmet, Saiya-Cork Kamlai, Shedden Kerby, Malek Sami N

Abstract excerpt

PURPOSE: Recurrent gene mutations, chromosomal translocations, and acquired genomic copy number aberrations (aCNA) have been variously associated with acute myelogenous leukemia (AML) patient outcome. However, knowledge of the co-occurrence of such lesions and the relative influence of different types of genomic alterations on clinical outcomes in AML is still evolving. EXPERIMENTAL DESIGN: We performed SNP 6.0...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Loss of Heterozygosity

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Source

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Identifiers

PMID: 25652455
DOI: 10.1158/1078-0432.CCR-14-0921
PMCID: PMC4417381

Genes

TP53
RUNX1
NPM1
ASXL1
DNMT3A
FLT3
IDH1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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