Acquired copy number alterations in adult acute myeloid leukemia genomes.

doi:10.1073/pnas.0903091106

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Article

Acquired copy number alterations in adult acute myeloid leukemia genomes.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2009

Walter Matthew J, Payton Jacqueline E, Ries Rhonda E, Shannon William D, Deshmukh Hrishikesh, Zhao Yu, Baty Jack, Heath Sharon, Westervelt Peter, Watson Mark A, Tomasson Michael H, Nagarajan Rakesh, O'Gara Brian P, Bloomfield Clara D, Mrózek Krzysztof, Selzer Rebecca R, Richmond Todd A, Kitzman Jacob, Geoghegan Joel, Eis Peggy S, Maupin Rachel, Fulton Robert S, McLellan Michael, Wilson Richard K, Mardis Elaine R, Link Daniel C, Graubert Timothy A, DiPersio John F, Ley Timothy J

Abstract excerpt

Cytogenetic analysis of acute myeloid leukemia (AML) cells has accelerated the identification of genes important for AML pathogenesis. To complement cytogenetic studies and to identify genes altered in AML genomes, we performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using 1.85 million feature SNP arrays. Acquired copy number alterations...

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Identifiers

PMID: 19651600
DOI: 10.1073/pnas.0903091106
PMCID: PMC2716381

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