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Article

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

The New England journal of medicine - 22 Mar 2012

Patel Jay P, Gönen Mithat, Figueroa Maria E, Fernandez Hugo, Sun Zhuoxin, Racevskis Janis, Van Vlierberghe Pieter, Dolgalev Igor, Thomas Sabrena, Aminova Olga, Huberman Kety, Cheng Janice, Viale Agnes, Socci Nicholas D, Heguy Adriana, Cherry Athena, Vance Gail, Higgins Rodney R, Ketterling Rhett P, Gallagher Robert E, Litzow Mark, van den Brink Marcel R M, Lazarus Hillard M, Rowe Jacob M, Luger Selina, Ferrando Adolfo, Paietta Elisabeth, Tallman Martin S, Melnick Ari, Abdel-Wahab Omar, Levine Ross L

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated in a phase 3 trial of treatment for AML. METHODS: We performed a mutational analysis of 18 genes in 398 patients younger than 60 years of age who had AML and who were randomly assigned to receive...

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Identifiers

PMID: 22417203
DOI: 10.1056/NEJMoa1112304
PMCID: PMC3545649

Genes

NPM1
DNMT3A
FLT3
IDH2
ASXL1
PHF6
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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