Article
The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients.
Inflammation - 1 Aug 2015
Panek Michał, Pietras Tadeusz, Fabijan Artur, Zioło Jan, Wieteska Łukasz, Małachowska Beata, Fendler Wojciech, Szemraj Janusz, Kuna Piotr
Abstract excerpt
Glucocorticosteroids (GCs) are basic drugs in therapy of a number of diseases, including chronic diseases of the respiratory system. They are the most important anti-inflammatory drugs in the treatment of asthma. GCs after binding to the glucocorticoid receptor (GR) form the complex (transcription factor), which acts on promoter and regulatory parts of genes enhancing the expression of anti-inflammatory proteins...
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