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Article

Mixture SNPs effect on phenotype in genome-wide association studies.

BMC genomics - 3 Feb 2015

Wang Ling, Shen Haipeng, Liu Hexuan, Guo Guang

Abstract excerpt

BACKGROUND: Recently mixed linear models are used to address the issue of "missing" heritability in traditional Genome-wide association studies (GWAS). The models assume that all single-nucleotide polymorphisms (SNPs) are associated with the phenotypes of interest. However, it is more common that only a small proportion of SNPs have significant effects on the phenotypes, while most SNPs have no or very small...

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PMID: 25649116
DOI: 10.1186/1471-2164-16-3
PMCID: PMC4417323

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