Article
Direct genetic effects and their estimation from matched case-control data.
Genetic epidemiology - 1 Sept 2012
Berzuini Carlo, Vansteelandt Stijn, Foco Luisa, Pastorino Roberta, Bernardinelli Luisa
Abstract excerpt
In genetic association studies, a single marker is often associated with multiple, correlated phenotypes (e.g., obesity and cardiovascular disease, or nicotine dependence and lung cancer). A pervasive question is then whether that marker exerts independent effects on all phenotypes. In this paper, we address this question by assessing whether there is a genetic effect on one phenotype that is not mediated through...
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