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Article

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.

Bioinformatics (Oxford, England) - 15 Oct 2014

Pasaniuc Bogdan, Zaitlen Noah, Shi Huwenbo, Bhatia Gaurav, Gusev Alexander, Pickrell Joseph, Hirschhorn Joel, Strachan David P, Patterson Nick, Price Alkes L

Abstract excerpt

MOTIVATION: Imputation using external reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies and meta-analysis. Existing hidden Markov models (HMM)-based imputation approaches require individual-level genotypes. Here, we develop a new method for Gaussian imputation from summary association statistics, a type of data that is becoming widely available....

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Identifiers

PMID: 24990607
DOI: 10.1093/bioinformatics/btu416
PMCID: PMC4184260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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