A Bayesian approach to genetic association studies with family-based designs.

Abstract excerpt

For genome-wide association studies with family-based designs, we propose a Bayesian approach. We show that standard transmission disequilibrium test and family-based association test statistics can naturally be implemented in a Bayesian framework, allowing flexible specification of the likelihood and prior odds. We construct a Bayes factor conditional on the offspring phenotype and parental genotype data and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Asthma
• Share to Bayes Theorem
• Share to Body Mass Index