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Article

PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition

4 Feb 2015

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) is a central developmental process implicated in cancer metastasis. Here we show that the tyrosine kinase PYK2 enhances cell migration and invasion and potentiates EMT in human breast carcinoma. EMT inducer, such as EGF, induces rapid phosphorylation of PYK2 and its translocation to early endosomes where it co-localizes with EGFR and sustains its downstream signals....

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PMID: 25648557
DOI: 10.1038/ncomms7064

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