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Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer

8 May 2018

Abstract excerpt

Focal adhesion kinase (FAK) and its homologous FAK-related proline-rich tyrosine kinase 2 (Pyk2) contain the same domain, exhibit high sequence homology and are defined as a distinct family of non-receptor tyrosine kinases. This group of kinases plays critical roles in cytoskeletal dynamics and cell adhesion by regulating survival and growth signaling. This review summarizes the physiological and pathological...

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PMID: 29738483
DOI: 10.3390/cancers10050139

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