Article

Met-HER3 crosstalk supports proliferation via MPZL3 in <i>MET</i> -amplified cancer cells

2021-07-27

Abstract excerpt

<h4>ABSTRACT</h4> Receptor tyrosine kinases (RTKs) are recognized as targets of precision medicine in human cancer upon their gene amplification or constitutive activation, resulting in increased downstream signal complexity including heterotypic crosstalk with other RTKs. The Met RTK exhibits such reciprocal crosstalk with several members of the human EGFR (HER) family of RTKs when amplified in cancer cells. We...

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Literature Corpus work: a80134a9-95e1-59e7-8728-4c52de199e1e
DOI: 10.1101/2021.07.27.454013

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