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Article

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration.

Biochemical and biophysical research communications - 27 Oct 2006

Lipinski Christopher A, Tran Nhan L, Dooley Andrea, Pang Yuan-Ping, Rohl Carole, Kloss Jean, Yang Zhongbo, McDonough Wendy, Craig David, Berens Michael E, Loftus Joseph C

Abstract excerpt

The strong tendency of malignant glioma cells to invade locally into surrounding normal brain precludes effective surgical resection, reduces the efficacy of radiotherapy, and is associated with increased resistance to chemotherapy regimens. We report that the N-terminal FERM domain of Pyk2 regulates its promigratory function. A 3-dimensional model of the Pyk2 FERM domain was generated and mutagenesis studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16962067
DOI: 10.1016/j.bbrc.2006.08.134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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