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Article

Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis

13 Jan 2025

Abstract excerpt

• EGFR heterodimerizes with NOK/STYK1, a novel tyrosine kinase with a transmembrane domain, in a manner of cross interaction via their juxtamembrane (JM) domains and kinase domains. • NOK enhances EGF signaling activation, in particular, the phosphorylation of STAT3 and STAT5 via its JM domain. • NOK and EGFR synergistically promote proliferation and migration of breast cancer cells and induce tumorigenesis of...

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PMID: 39808846
DOI: 10.1016/j.tranon.2025.102276

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