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Article

Met–HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells

1 Mar 2022

Abstract excerpt

Receptor tyrosine kinases (RTKs) are recognized as targets of precision medicine in human cancer upon their gene amplification or constitutive activation, resulting in increased downstream signal complexity including heterotypic crosstalk with other RTKs. The Met RTK exhibits such reciprocal crosstalk with several members of the human EGFR (HER) family of RTKs when amplified in cancer cells. We show that Met...

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PMID: 35249128
DOI: 10.1007/s00018-022-04149-w

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