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Article

Altered p53 and NOX1 activity cause bioenergetic defects in a SCA7 polyglutamine disease model.

Biochimica et biophysica acta - 1 Jan 2000

Ajayi Abiodun, Yu Xin, Wahlo-Svedin Carolina, Tsirigotaki Galateia, Karlström Victor, Ström Anna-Lena

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is one of the nine neurodegenerative disorders caused by expanded polyglutamine (polyQ) domains. Common pathogenic mechanisms, including bioenergetics defects, have been suggested for these so called polyQ diseases. However, the exact molecular mechanism(s) behind the metabolic dysfunction is still unclear. In this study we identified a previously unreported mechanism,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25647692
DOI: 10.1016/j.bbabio.2015.01.012

Genes

NOX1
ATXN7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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