Article

SCA7 mouse cerebellar pathology reveals preferential downregulation of key Purkinje cell-identity genes and shared disease signature with SCA1 and SCA2.

2020-07-23

Abstract excerpt

<title>Abstract</title> <p>Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease mainly characterized by motor incoordination and visual impairment due to progressive cerebellar and retinal degeneration. Alteration of other nervous tissues also contributes to symptoms. The mechanisms underlying motor incoordination of SCA7 remain to be characterized. SCA7 is caused by a polyglutamine (pol...

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Literature Corpus work: bd497495-39ba-549a-96aa-db509de3a6a3
DOI: 10.21203/rs.3.rs-27474/v2

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