Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Mar 2007

Latouche Morwena, Lasbleiz Christelle, Martin Elodie, Monnier Véronique, Debeir Thomas, Mouatt-Prigent Annick, Muriel Marie-Paule, Morel Lydie, Ruberg Merle, Brice Alexis, Stevanin Giovanni, Tricoire Hérvé

Abstract excerpt

Spinocerebellar ataxia 7 (SCA7) is a neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the ataxin 7 (ATXN7) protein, a member of a multiprotein complex involved in histone acetylation. We have created a conditional Drosophila model of SCA7 in which expression of truncated ATXN7 (ATXN7T) with a pathogenic polyQ expansion is induced in neurons in adult flies. In this model, mutant ATXN7T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxin-7
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dyskinesias

Share to Glutamine

Share to Intranuclear Inclusion Bodies

Share to Longevity

Share to Spinocerebellar Ataxias

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 17344386
DOI: 10.1523/JNEUROSCI.5453-06.2007
PMCID: PMC6672519

Genes

ATXN7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.PMID 17344386Read ↗

Progressive degeneration in a new Drosophila model of Spinocerebellar Ataxia type 7Semantic proximity Read ↗

Progressive degeneration in a new <i>Drosophila</i> model of Spinocerebellar Ataxia type 7Semantic proximity Read ↗

Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice.Semantic proximity Read ↗

Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.Semantic proximity Read ↗

Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7.Semantic proximity Read ↗

Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.Semantic proximity Read ↗

Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model.Semantic proximity Read ↗

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types.Semantic proximity Read ↗

Phenotypic defects from the expression of wild-type and pathogenic TATA-Binding Proteins in new <i>Drosophila</i> models of Spinocerebellar Ataxia Type 17Semantic proximity Read ↗

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.Semantic proximity Read ↗

Allele-specific silencing of mutant Ataxin-7 in SCA7 patient-derived fibroblasts.Semantic proximity Read ↗

Insights into dentatorubral-pallidoluysian atrophy from a new Drosophila model of diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.