Article

The stress granule protein G3BP1 reduces the levels of polyglutamine proteins and alleviates spinocerebellar ataxia associated deficits

2022-11-22

Abstract excerpt

<title>Abstract</title> <p> Polylgutamine (polyQ) diseases are a group of neurodegenerative disorders caused by abnormal expansion of CAG repeat tracts in the codifying regions of nine, otherwise unrelated, genes. While the protein products of these genes are suggested to play diverse cell roles, the pathogenic mutant proteins bearing an expanded polyQ sequence share a tendency to self-assemble, aggregate, and e...

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Literature Corpus work: 889cd893-9bb6-5596-ae78-c8e808bb2073
DOI: 10.21203/rs.3.rs-668663/v2

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