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Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6

29 Jan 2024

Abstract excerpt

Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that manifests in midlife and progressively worsens with age. SCA6 is rare, and many patients are not diagnosed until long after disease onset. Whether disease-causing cellular alterations differ at different disease stages is currently unknown, but it is important to answer this question in order to identify appropriate therapeutic targets...

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PMID: 38286873
DOI: 10.1007/s00401-023-02680-z

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