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Article

Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model.

Journal of molecular neuroscience : MN - 1 Jul 2013

Yu Xin, Muñoz-Alarcón Andrés, Ajayi Abiodun, Webling Kristin E, Steinhof Anne, Langel Ülo, Ström Anna-Lena

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is one of nine neurodegenerative disorders caused by expanded polyglutamine domains. These so-called polyglutamine (polyQ) diseases are all characterized by aggregation. Reducing the level of aggregating polyQ proteins via pharmacological activation of autophagy has been suggested as a therapeutic approach. However, recently, evidence implicating autophagic dysfunction in...

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Source

Identifiers

PMID: 23592174
DOI: 10.1007/s12031-013-0012-x

Genes

ATXN7
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model.PMID 23592174Read ↗

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