Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome substitution strain assessment of a Huntington's disease modifier locus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2015

Ramos Eliana Marisa, Kovalenko Marina, Guide Jolene R, St Claire Jason, Gillis Tammy, Mysore Jayalakshmi S, Sequeiros Jorge, Wheeler Vanessa C, Alonso Isabel, MacDonald Marcy E

Abstract excerpt

Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human-mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23-24 linkage interval. This unbiased strategy employs C57BL/6J...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine and cAMP-Regulated Phosphoprotein 32

Share to Gene Knock-In Techniques

Share to Genomic Instability

Share to Huntingtin Protein

Share to Huntington Disease

Share to Trinucleotide Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 25645993
DOI: 10.1007/s00335-014-9552-9
PMCID: PMC4372682

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome substitution strain assessment of a Huntington's disease modifier locus.PMID 25645993Read ↗

C57BL/6 BAC-CAG Huntington’s disease mice show somatic CAG expansion and responses to small interfering RNAs comparable to the FVB strainSemantic proximity Read ↗

Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s diseaseSemantic proximity Read ↗

A novel and accurate full-length HTT mouse model for Huntington’s diseaseSemantic proximity Read ↗

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.Semantic proximity Read ↗

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.Semantic proximity Read ↗

C57BL/6-derived mice and the Cdh23ahl allele - Background matters.Semantic proximity Read ↗

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.Semantic proximity Read ↗

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.Semantic proximity Read ↗

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.Semantic proximity Read ↗

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.Semantic proximity Read ↗

Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains.Semantic proximity Read ↗

Huntington's disease: the case for genetic modifiersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.