Article

C57BL/6 BAC-CAG Huntington’s disease mice show somatic CAG expansion and responses to small interfering RNAs comparable to the FVB strain

2026-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene, with longer repeats linked to earlier onset. Somatic CAG expansion, particularly in the striatum, contributes to disease progression and is influenced by HTT biology and genetic modifiers. Modulating somatic expansion is emerging as a promising approach to slow or prevent HD, an...

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Literature Corpus work: 91a4da6f-dc2f-56b0-a7c3-db33db7bea35
DOI: 10.64898/2026.05.08.723329

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