Article

A novel and accurate full-length HTT mouse model for Huntington’s disease

2021-06-14

Abstract excerpt

Here we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using a bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ∼226 CAG-CAA repeats and containing endogenous human HTT promoter and regulatory elements. BAC226Q recapitulated a full-spectrum of age-dependent and progressive HD-like phenotypes without unwanted and erroneous ph...

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Literature Corpus work: af61adbf-643f-53ba-a19a-3ed2638bc2e1
DOI: 10.1101/2021.06.14.448318

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