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Article

Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains.

Scientific reports - 13 Mar 2017

Johnson Kenneth R, Tian Cong, Gagnon Leona H, Jiang Haiyan, Ding Dalian, Salvi Richard

Abstract excerpt

A single nucleotide variant (SNV) of the cadherin 23 gene (Cdh23c.753A), common to many inbred mouse strains, accelerates age-related hearing loss (AHL) and can worsen auditory phenotypes of other mutations. We used homologous recombination in C57BL/6 NJ (B6N) and 129S1/SvImJ (129S1) embryonic stem cells to engineer mouse strains with reciprocal single base pair substitutions (B6-Cdh23c.753A>G and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Evoked Potentials, Auditory, Brain Stem

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Identifiers

PMID: 28287619
DOI: 10.1038/srep44450
PMCID: PMC5347380

Genes

ABR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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