Article
A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.
Human molecular genetics - 15 May 2018
Corrochano Silvia, Blanco Gonzalo, Williams Debbie, Wettstein Jessica, Simon Michelle, Kumar Saumya, Moir Lee, Agnew Thomas, Stewart Michelle, Landman Allison, Kotiadis Vassilios N, Duchen Michael R, Wackerhage Henning, Rubinsztein David C, Brown Steve D M, Acevedo-Arozena Abraham
Abstract excerpt
Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine tract explain up to 70% of the age-at-onset variance, with the rest of the variance attributed to genetic and environmental modifiers. To identify novel disease modifiers, we performed an...
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