Article
The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.
Gut - 1 Mar 2016
Grimm Wesley A, Messer Jeannette S, Murphy Stephen F, Nero Thomas, Lodolce James P, Weber Christopher R, Logsdon Mark F, Bartulis Sarah, Sylvester Brooke E, Springer Amanda, Dougherty Urszula, Niewold Timothy B, Kupfer Sonia S, Ellis Nathan, Huo Dezheng, Bissonnette Marc, Boone David L
Abstract excerpt
OBJECTIVE: ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer. Mechanisms underlying this observation have not been proposed, nor is it clear whether an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.