Article
Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish.
Brain : a journal of neurology - 3 Mar 2021
Luo Juanjuan, Liu Pei, Lu Chunjiao, Bian Wanping, Su Dongsheng, Zhu Chenchen, Xie Shaolin, Pan Yihang, Li Ningning, Cui Wei, Pei De-Sheng, Yang Xiaojun
Abstract excerpt
The molecular pathogenesis of glioblastoma indicates that RTK/Ras/PI3K, RB and TP53 pathways are critical for human gliomagenesis. Here, several transgenic zebrafish lines with single or multiple deletions of nf1, tp53 and rb1 in astrocytes, were established to genetically induce gliomagenesis in zebrafish. In the mutant with a single deletion, we found only the nf1 mutation low-efficiently induced tumour...
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