Article
Constitutive activation of Raf-1 induces glioma formation in mice.
Neoplasia (New York, N.Y.) - 1 May 2008
Lyustikman Yelena, Momota Hiroyuki, Pao William, Holland Eric C
Abstract excerpt
In human glioblastoma multiforme (GBM), RAS activity is upregulated in the majority of the tumors. Furthermore, the levels of phospho-mitogen-activated protein kinase/extracellular signal regulated kinase (MAPK/ERK), a downstream effector of RAS, are also increased. In mice, activated KRas cooper...
Topics
- Animals
- Animals, Newborn
- Blotting, Western
- Brain
- Brain Neoplasms
- Cyclin-Dependent Kinase Inhibitor p16
- Genes, ras
- Glioblastoma
- Humans
- Immunoenzyme Techniques
- Mice
- Mice, Knockout
- Mutation
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-raf