4H-CRCXL Mitigates RasV12-Induced Phenotypes in Glioblastoma Model of Drosophila.

doi:10.1002/mc.70161

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Article

4H-CRCXL Mitigates RasV12-Induced Phenotypes in Glioblastoma Model of Drosophila.

Molecular carcinogenesis - 1 Oct 2026

Kumar Pradeep, Raghuvanshi Vaishali, Kumar Prabhat, Kumar Rohit, Chauhan Brijesh Singh, Katiyar Diksha, Srikrishna Saripella

Abstract excerpt

Glioblastoma (GBM), a Grade IV malignant brain tumor, accounts for over half of all gliomas and remains resistant to current therapies, requiring the development of novel treatment strategies. Aberrant Ras signaling and PI3K/Akt hyperactivation and RAF/MEK/ERK pathways are major oncogenic drivers, implicated in approximately 30% of cancers, including GBM. Chromenes, particularly 4H-chromenes, possess diverse...

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Topics

Animals
Glioblastoma
Drosophila melanogaster
Brain Neoplasms
Benzopyrans
Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Humans

Signal Transduction

Apoptosis

Antineoplastic Agents

ras Proteins

Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 42561124
DOI: 10.1002/mc.70161
PMCID: PMC13576868

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