Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fast linkage analysis with MOD scores using algebraic calculation.

Human heredity - 1 Jan 2014

Brugger Markus, Strauch Konstantin

Abstract excerpt

OBJECTIVE: As the mode of inheritance is often unknown for complex diseases, a MOD-score analysis, in which the parametric LOD score is maximized with respect to the trait-model parameters, can be a powerful approach in genetic linkage analysis. Because the calculation of the disease-locus likelihood is the most time-consuming step in a MOD-score analysis, we aimed to optimize this part of the calculation to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Genetic Linkage
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Heredity

Share to Markov Chains

Share to Pedigree

Share to Software

Source

Identifiers

PMID: 25633962
DOI: 10.1159/000369065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fast linkage analysis with MOD scores using algebraic calculation.PMID 25633962Read ↗

Joint Linkage and Association Analysis Using GENEHUNTER-MODSCORE with an Application to Familial Pancreatic Cancer.Semantic proximity Read ↗

Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE.Semantic proximity Read ↗

Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.Semantic proximity Read ↗

Linkage analysis of alcohol dependence using MOD scores.Semantic proximity Read ↗

Parameter estimation and quantitative parametric linkage analysis with GENEHUNTER-QMOD.Semantic proximity Read ↗

[Linkage analysis for complex diseases: a new life for an old method].Semantic proximity Read ↗

Multivariate and multilocus variance components method, based on structural relationships to assess quantitative trait linkage via SEGPATH.Semantic proximity Read ↗

MQScore_SNP software for multipoint parametric linkage analysis of quantitative traits in large pedigrees.Semantic proximity Read ↗

Logarithm of odds (lods) for linkage in complex inheritance.Semantic proximity Read ↗

Exact genetic linkage computations for general pedigrees.Semantic proximity Read ↗

Conditional likelihood score functions for mixed models in linkage analysis.Semantic proximity Read ↗

Model-free linkage analysis: performance under real-world conditions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.