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Article

Parameter estimation and quantitative parametric linkage analysis with GENEHUNTER-QMOD.

Human heredity - 1 Jan 2012

Künzel Thomas, Strauch Konstantin

Abstract excerpt

OBJECTIVE: We present a parametric method for linkage analysis of quantitative phenotypes. The method provides a test for linkage as well as an estimate of different phenotype parameters. We have implemented our new method in the program GENEHUNTER-QMOD and evaluated its properties by performing simulations. METHODS: The phenotype is modeled as a normally distributed variable, with a separate distribution for...

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PMID: 22948723
DOI: 10.1159/000339904

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