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Article

Spatio-temporal regulation of RAG2 following genotoxic stress.

DNA repair - 1 Mar 2015

Rodgers William, Byrum Jennifer N, Sapkota Hem, Rahman Negar S, Cail Robert C, Zhao Shuying, Schatz David G, Rodgers Karla K

Abstract excerpt

V(D)J recombination of lymphocyte antigen receptor genes occurs via the formation of DNA double strand breaks (DSBs) through the activity of RAG1 and RAG2. The co-existence of RAG-independent DNA DSBs generated by genotoxic stressors potentially increases the risk of incorrect repair and chromoso...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25625798
DOI: 10.1016/j.dnarep.2014.12.008
PMCID: PMC4336829

Genes

RAG2
ATM
RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25625798-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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