Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Full length RAG2 expression enhances the DNA damage response in pre-B cells.

Immunobiology - 1 May 2021

Byrum Jennifer N, Hoolehan Walker E, Simpson Destiny A, Rodgers William, Rodgers Karla K

Abstract excerpt

V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export from the nucleus and enrichment at the centrosome minutes following production of DSBs by genotoxic stress, suggesting that RAG2 participates in cellular responses to DSBs such as those generated during V(D)J recombination. To determine the effect of RAG2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to DNA-Binding Proteins
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Gene Expression

Share to Nuclear Proteins

Share to Precursor Cells, B-Lymphoid

Share to V(D)J Recombination

Source

Open in PubMed Open full text

Identifiers

PMID: 33873062
DOI: 10.1016/j.imbio.2021.152089
PMCID: PMC8169632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Full length RAG2 expression enhances the DNA damage response in pre-B cells.PMID 33873062Read ↗

Spatio-temporal regulation of RAG2 following genotoxic stress.Semantic proximity Read ↗

Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.Semantic proximity Read ↗

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle.Semantic proximity Read ↗

RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.Semantic proximity Read ↗

Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.Semantic proximity Read ↗

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.Semantic proximity Read ↗

RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferationSemantic proximity Read ↗

Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Semantic proximity Read ↗

Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.Semantic proximity Read ↗

RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombinationSemantic proximity Read ↗

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.Semantic proximity Read ↗

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.