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Article

Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6.

Human mutation - 1 Mar 2016

Qiao Wanqiong, Yang Yao, Sebra Robert, Mendiratta Geetu, Gaedigk Andrea, Desnick Robert J, Scott Stuart A

Abstract excerpt

The cytochrome P450-2D6 (CYP2D6) enzyme metabolizes ∼25% of common medications, yet homologous pseudogenes and copy number variants (CNVs) make interrogating the polymorphic CYP2D6 gene with short-read sequencing challenging. Therefore, we developed a novel long-read, full gene CYP2D6 single molecule real-time (SMRT) sequencing method using the Pacific Biosciences platform. Long-range PCR and CYP2D6 SMRT...

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Identifiers

PMID: 26602992
DOI: 10.1002/humu.22936
PMCID: PMC4752389

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Source receipt: pubmed, retrieved 7 Sept 2026.

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