Article
Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2015
Dal Molin Marco, Zhang Ming, de Wilde Roeland F, Ottenhof Niki A, Rezaee Neda, Wolfgang Christopher L, Blackford Amanda, Vogelstein Bert, Kinzler Kenneth W, Papadopoulos Nickolas, Hruban Ralph H, Maitra Anirban, Wood Laura D
Abstract excerpt
PURPOSE: The median survival following surgical resection of pancreatic ductal adenocarcinoma (PDAC) is currently <20 months. However, survival ≥10 years is achieved by a small subset of patients who are defined as very long-term survivors (VLTS). The goal of this study was to determine whether specific genetic alterations in resected PDACs determined very long-term survival. EXPERIMENTAL DESIGN: We sequenced the...
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