SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.

doi:10.1158/1078-0432.CCR-09-0227

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Article

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2009

Blackford Amanda, Serrano Oscar K, Wolfgang Christopher L, Parmigiani Giovanni, Jones Siân, Zhang Xiaosong, Parsons D Williams, Lin Jimmy Cheng-Ho, Leary Rebecca J, Eshleman James R, Goggins Michael, Jaffee Elizabeth M, Iacobuzio-Donahue Christine A, Maitra Anirban, Cameron John L, Olino Kelly, Schulick Richard, Winter Jordan, Herman Joseph M, Laheru Daniel, Klein Alison P, Vogelstein Bert, Kinzler Kenneth W, Velculescu Victor E, Hruban Ralph H

Abstract excerpt

PURPOSE: Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas. EXPERIMENTAL DESIGN: We previously sequenced more than 75...

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Identifiers

PMID: 19584151
DOI: 10.1158/1078-0432.CCR-09-0227
PMCID: PMC2819274

Genes

SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19584151-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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