Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma.

doi:10.1001/jamaoncol.2017.3420

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Article

Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma.

JAMA oncology - 8 Mar 2018

Qian Zhi Rong, Rubinson Douglas A, Nowak Jonathan A, Morales-Oyarvide Vicente, Dunne Richard F, Kozak Margaret M, Welch Marisa W, Brais Lauren K, Da Silva Annacarolina, Li Tingting, Li Wanwan, Masuda Atsuhiro, Yang Juhong, Shi Yan, Gu Mancang, Masugi Yohei, Bui Justin, Zellers Caitlin L, Yuan Chen, Babic Ana, Khalaf Natalia, Aguirre Andrew, Ng Kimmie, Miksad Rebecca A, Bullock Andrea J, Chang Daniel T, Tseng Jennifer F, Clancy Thomas E, Linehan David C, Findeis-Hosey Jennifer J, Doyle Leona A, Thorner Aaron R, Ducar Matthew, Wollison Bruce, Laing Angelica, Hahn William C, Meyerson Matthew, Fuchs Charles S, Ogino Shuji, Hornick Jason L, Hezel Aram F, Koong Albert C, Wolpin Brian M

Abstract excerpt

IMPORTANCE: Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers are available to inform patient outcomes. OBJECTIVE: To evaluate the alterations of the 4 main driver genes in pancreatic adenocarcinoma and patient outcomes after cancer resection. DESIGN, SETTING, AND PARTICIPANTS: This study analyzed protein expression and DNA alterations for the KRAS,...

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Identifiers

PMID: 29098284
DOI: 10.1001/jamaoncol.2017.3420
PMCID: PMC5844844

Genes

KRAS
SMAD4

Variants

Provenance

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