Article
Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.
Cancer - 1 Sept 2020
McIntyre Caitlin A, Lawrence Sharon A, Richards Allison L, Chou Joanne F, Wong Winston, Capanu Marinela, Berger Michael F, Donoghue Mark T A, Yu Kenneth H, Varghese Anna M, Kelsen David P, Park Wungki, Balachandran Vinod P, Kingham T Peter, D'Angelica Michael I, Drebin Jeffrey A, Jarnagin William R, Iacobuzio-Donahue Christine A, Allen Peter J, O'Reilly Eileen M
Abstract excerpt
BACKGROUND: KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways are associated with clinical outcomes for individuals who undergo resection. METHODS: Eligible individuals were those who underwent resection of PDAC and consented to targeted...
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