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Article

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma.

Archives of pathology & laboratory medicine - 1 Dec 2024

Chao Timothy, Wang Zi-Xuan, Bowne Wilbur B, Yudkoff Clifford J, Torjani Ava, Swaminathan Vishal, Kavanagh Taylor R, Roadarmel Austin, Sholevar Cyrus J, Cannaday Shawnna, Krampitz Geoffrey, Zhan Tingting, Gorgov Eliyahu, Nevler Avinoam, Lavu Harish, Yeo Charles J, Peiper Stephen C, Jiang Wei

Abstract excerpt

CONTEXT.—: Mutant KRAS is the main oncogenic driver in pancreatic ductal adenocarcinomas (PDACs). However, the clinical and phenotypic implications of harboring different mutant KRAS alleles remain poorly understood. OBJECTIVE.—: To characterize the potential morphologic and clinical outcome differences in PDACs harboring distinct mutant KRAS alleles. DESIGN.—: Cohort 1 consisted of 127 primary conventional PDACs...

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Aged, 80 and over
Alleles
Carcinoma, Pancreatic Ductal
Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Pancreatic Neoplasms

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 38452805
DOI: 10.5858/arpa.2023-0005-OA

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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