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Article

P53 Function Status Correlates With Overall Survival in Patients With Resected Pancreatic Cancer.

Journal of surgical oncology - 1 Oct 2025

Chen Hui, Agarwal Alisha, Yellanki Sreekanth, Lavu Harish, Zheng Richard, Bowne Wilbur B, Yeo Charles J, Jain Aditi, Nevler Avinoam

Abstract excerpt

BACKGROUND: The P53 gene is the most common tumor-suppressor gene mutated in pancreatic ductal adenocarcinoma (PDAC). The gene's normal function is critical for regulation of replication, DNA repair, and apoptosis. The purpose of our study is to determine the impact of the various P53 mutation subtypes on survival in resected PDAC. METHODS: This is a retrospective cohort study assessing patients that underwent...

Read the complete abstract on PubMed

Topics

Humans
Pancreatic Neoplasms
Female
Male
Retrospective Studies
Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Aged

Middle Aged

Mutation

Survival Rate

Prognosis

Aged, 80 and over

Adult

Follow-Up Studies

Biomarkers, Tumor

Pancreatectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 40772622
DOI: 10.1002/jso.70060
PMCID: PMC12501923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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