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Article

Targeted next-generation sequencing of commonly mutated genes in esophageal adenocarcinoma patients with long-term survival.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Sept 2017

Visser E, Franken I A, Brosens L A A, de Leng W W J, Strengman E, Offerhaus J A, Ruurda J P, van Hillegersberg R

Abstract excerpt

Survival of patients with esophageal adenocarcinoma remains poor and individual differences in prognosis remain unexplained. This study investigated whether gene mutations can explain why patients with high-risk (pT3-4, pN+) esophageal adenocarcinoma survive past 5 years after esophagectomy. Six long-term survivors (LTS) (≥5 years survival without recurrence) and six short-term survivors (STS) (<2 years survival...

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Source

Identifiers

PMID: 28859360
DOI: 10.1093/dote/dox058

Genes

STS
CDH11
FAT4
TLR4
APC
KRAS
PTPRD
SMAD4
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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