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Article

Local communication among mucosal immune cells in patients with celiac disease.

Gastroenterology - 1 May 2015

van Bergen Jeroen, Mulder Chris J, Mearin M Luisa, Koning Frits

Abstract excerpt

In patients with celiac disease, gluten consumption causes inflammation of the duodenum, and, to a lesser extent, the proximal jejunum. Immune-dominant gluten peptides are modified by the enzyme TG2, leading to their high-affinity binding to HLA-DQ2 or HLA-DQ8 molecules, present in people with a predisposition to celiac disease. Gluten peptide-loaded HLA-DQ2 or HLA-DQ8 molecules are recognized by highly conserved...

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Source

Identifiers

PMID: 25623043
DOI: 10.1053/j.gastro.2015.01.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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