Article
Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.
Neoplasia (New York, N.Y.) - 1 Jan 2015
Cai Kathy Qi, Wang Ying, Smith Elizabeth R, Smedberg Jennifer L, Yang Dong-Hua, Yang Wan-Lin, Xu Xiang-Xi
Abstract excerpt
White spotting variant (Wv) mice are spontaneous mutants attributed to a point mutation in the c-Kit gene, which reduces the tyrosine kinase activity to around 1% and affects the development of melanocytes, mast cells, and germ cells. Homozygous mutant mice are sterile but can live nearly a norma...
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