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Article

Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.

Molecular and cellular biology - 15 Sept 2016

Wang Ying, Cai Kathy Qi, Smith Elizabeth R, Yeasky Toni M, Moore Robert, Ganjei-Azar Parvin, Klein-Szanto Andres J, Godwin Andrew K, Hamilton Thomas C, Xu Xiang-Xi

Abstract excerpt

We modeled the etiology of postmenopausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, incorporating oncogenic mutations. Ovarian cancer incidence is highest in peri- and postmenopausal women, and epidemiological studies have established the impact of reproductive factors on ovarian cancer risk. Menopause as a result of ovarian follicle depletion is thought to...

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Source

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Identifiers

PMID: 27354067
DOI: 10.1128/MCB.00202-16
PMCID: PMC5007791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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