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Article

Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells.

Neoplasia (New York, N.Y.) - 1 Jan 2015

Gajula Rajendra P, Chettiar Sivarajan T, Williams Russell D, Nugent Katriana, Kato Yoshinori, Wang Hailun, Malek Reem, Taparra Kekoa, Cades Jessica, Annadanam Anvesh, Yoon A-Rum, Fertig Elana, Firulli Beth A, Mazzacurati Lucia, Burns Timothy F, Firulli Anthony B, An Steven S, Tran Phuoc T

Abstract excerpt

The TWIST1 gene has diverse roles in development and pathologic diseases such as cancer. TWIST1 is a dimeric basic helix-loop-helix (bHLH) transcription factor existing as TWIST1-TWIST1 or TWIST1-E12/47. TWIST1 partner choice and DNA binding can be influenced during development by phosphorylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25622896
DOI: 10.1016/j.neo.2014.10.009
PMCID: PMC4309734

Genes

TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25622896-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells.PMID 25622896Read ↗

Phosphoregulation of Twist1 provides a mechanism of cell fate control.Semantic proximity Read ↗

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Regulation of Cancer Cell Survival, Migration, and Invasion by Twist: AKT2 Comes to InterplaySemantic proximity Read ↗

Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.Semantic proximity Read ↗

Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to PaclitaxelSemantic proximity Read ↗

STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion.Semantic proximity Read ↗

TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.Semantic proximity Read ↗

Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells.Semantic proximity Read ↗

Effect and Mechanism of LncRNA-PBC11 in Regulating EMT Progression of Prostate Cancer CellsSemantic proximity Read ↗

TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cellsSemantic proximity Read ↗

Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1Semantic proximity Read ↗

Targeting MUC1-C Inhibits TWIST1 Signaling in Triple-Negative Breast CancerSemantic proximity Read ↗

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