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Article

Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target.

BMC cancer - 10 Mar 2017

Roberts Cai M, Shahin Sophia A, Loeza Joana, Dellinger Thanh H, Williams John C, Glackin Carlotta A

Abstract excerpt

BACKGROUND: Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit from a novel therapy preventing or reversing these changes. To this end, we have investigated the unique WR domain of the transcription factor TWIST1, which has been shown to play a role in...

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Source

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Identifiers

PMID: 28283022
DOI: 10.1186/s12885-017-3169-9
PMCID: PMC5345230

Genes

TWIST1
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target.PMID 28283022Read ↗

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A twist for survival and cancer progressionSemantic proximity Read ↗

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