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Article

Targeting MUC1-C Inhibits TWIST1 Signaling in Triple-Negative Breast Cancer

15 Jul 2019

Abstract excerpt

Abstract The oncogenic MUC1-C protein and the TWIST1 epithelial–mesenchymal transition transcription factor (EMT-TF) are aberrantly expressed in triple-negative breast cancer (TNBC) cells. However, there is no known association between MUC1-C and TWIST1 in TNBC or other cancer cells. Here, we show that MUC1-C activates STAT3, and that MUC1-C and pSTAT3 drive induction of the TWIST1 gene. In turn, MUC1-C binds...

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PMID: 31308076
DOI: 10.1158/1535-7163.mct-19-0156

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