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Article

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

Blood - 19 Mar 2015

Kinkel Sarah A, Galeev Roman, Flensburg Christoffer, Keniry Andrew, Breslin Kelsey, Gilan Omer, Lee Stanley, Liu Joy, Chen Kelan, Gearing Linden J, Moore Darcy L, Alexander Warren S, Dawson Mark, Majewski Ian J, Oshlack Alicia, Larsson Jonas, Blewitt Marnie E

Abstract excerpt

Polycomb repressive complex 2 (PRC2) plays a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is targeted to specific genomic loci within HSPCs remains unknown. Here we use short hairpin RNA-mediated knockdown to survey the function of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25645357
DOI: 10.1182/blood-2014-10-603969
PMCID: PMC4424268

Genes

JARID2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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