Article
PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.
Cardiovascular research - 1 Mar 2015
McLean Brent A, Zhabyeyev Pavel, Patel Vaibhav B, Basu Ratnadeep, Parajuli Nirmal, DesAulniers Jessica, Murray Allan G, Kassiri Zamaneh, Vanhaesebroeck Bart, Oudit Gavin Y
Abstract excerpt
AIMS: Genetic mouse models have yielded conflicting conclusions about the role of PI3Kα in heart physiology: specifically, the question of whether PI3Kα has a direct role in regulating myocardial contractility. This has led to concerns that PI3K inhibitors currently in clinical trials for cancer may potentiate cardiotoxicity. Here we seek to clarify the role of PI3Kα in normal heart physiology and investigate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.